Publication: Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization
Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization
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Nagarajan, S., Vohra, T., Loffing, J., & Faresse, N. (2017). Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization. Molecular and Cellular Endocrinology, 450, 74–82. https://doi.org/10.1016/j.mce.2017.04.020
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Stimulation of the mineralocorticoid receptor (MR) by aldosterone controls several physiological parameters including blood pressure, inflammation or metabolism. We previously showed that MR turnover constitutes a crucial regulatory step in the responses of renal epithelial cells to aldosterone. Here, we identified Protein Phosphatase 1 alpha (PP1α), as a novel cytoplasmic binding partner of MR that promotes the receptor activity. The RT-PCR expression mapping of PP1α reveals a high expression in the kidney, particularly in the distal
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- Nagarajan, Shunmugam
- Vohra, Twinkle
- Loffing, Johannes
- Faresse, Nourdine
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Nagarajan, S., Vohra, T., Loffing, J., & Faresse, N. (2017). Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization. Molecular and Cellular Endocrinology, 450, 74–82. https://doi.org/10.1016/j.mce.2017.04.020
