Publication: Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
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Leppänen, V.-M., Tvorogov, D., Kisko, K., Prota, A. E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K. N., Ballmer-Hofer, K., & Alitalo, K. (2013). Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 12960–12965. https://doi.org/10.1073/pnas.1301415110
Abstract
Abstract
Abstract
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficiency and for blocking tumor angiogenesis and metastasis. The extracellular domain of VEGFRs consists of seven Ig homology domains; domains 1-3 (D1-3) are responsible for ligand binding, and the membrane-proximal domains 4-7
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Creators (Authors)
- Leppänen, Veli-Matti
- Tvorogov, Denis
- Kisko, Kaisa
- Prota, Andrea E
- Jeltsch, Michael
- Anisimov, Andrey
- Markovic-Mueller, Sandra
- Stuttfeld, Edward
- Goldie, Kenneth N
- Ballmer-Hofer, Kurt
- Alitalo, Kari
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Citations
Leppänen, V.-M., Tvorogov, D., Kisko, K., Prota, A. E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K. N., Ballmer-Hofer, K., & Alitalo, K. (2013). Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 12960–12965. https://doi.org/10.1073/pnas.1301415110
