Publication: Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury
Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury
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Peukert, K., Fox, M., Schulz, S., Feuerborn, C., Frede, S., Putensen, C., Wrigge, H., Kümmerer, B. M., David, S., Seeliger, B., Welte, T., Latz, E., Klinman, D., Wilhelm, C., Steinhagen, F., & Bode, C. (2021). Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine, 204(1), 53–63. https://doi.org/10.1164/rccm.202005-1916OC
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Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with mortality up to 40%. Precision medicine approaches targeting patients based on their molecular phenotypes of ARDS might help to identify effective pharmacotherapies. The inflammasome-caspase-1 pathway contributes to the development of ARDS via IL-1β and IL-18 production. Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1β and IL-18 while the molecular mechanism by which tetracycline inhibits inflamm
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Peukert, K., Fox, M., Schulz, S., Feuerborn, C., Frede, S., Putensen, C., Wrigge, H., Kümmerer, B. M., David, S., Seeliger, B., Welte, T., Latz, E., Klinman, D., Wilhelm, C., Steinhagen, F., & Bode, C. (2021). Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine, 204(1), 53–63. https://doi.org/10.1164/rccm.202005-1916OC