Gentamicin plasma concentrations in hospitalized horses and retrospective minimal inhibitory concentrations of gram‐negative equine pathogens

Schoster, Angelika; Amsler Medvet, Morena; Kirchgaessner, Constanze; Saleh, Lanja; Schwarzwald, Colin C; Schmitt, Sarah

doi:10.1111/vec.13035

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Schoster, A., Amsler Medvet, M., Kirchgaessner, C., Saleh, L., Schwarzwald, C. C., & Schmitt, S. (2021). Gentamicin plasma concentrations in hospitalized horses and retrospective minimal inhibitory concentrations of gram‐negative equine pathogens. Journal of Veterinary Emergency and Critical Care, 31(3), 323–330. https://doi.org/10.1111/vec.13035

Abstract

Objectives: The optimal dosage regimen of gentamicin in horses is still under investigation. The objectives of this study were to determine gentamicin plasma concentrations in hospitalized horses treated with 10 mg/kg gentamicin (IV, q 24 h) and to determine whether a plasma concentration to minimum inhibitory concentration (MIC) ratio of 10:1 is reached for equine pathogens using this dose. Design: Prospective clinical observational study; retrospective study on MICs of 131 gram-negative bacteria isolated from horses (2012-2015). Set