Publication: A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
Date
Date
Date
Citations
Bardelli, M., Frontzek, K., Simonelli, L., Hornemann, S., Pedotti, M., Mazzola, F., Carta, M., Eckhardt, V., D’Antuono, R., Virgilio, T., González, S. F., Aguzzi, A., & Varani, L. (2018). A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity. PLoS Pathogens, 14(10), e1007335. https://doi.org/10.1371/journal.ppat.1007335
Abstract
Abstract
Abstract
Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective POM2, which bind the globular domain (GD) and flexible tail (FT) respectively. We found that scPOM-bi confers protection to prion-infected organotypi
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Bardelli, Marco
- Frontzek, Karl
- Simonelli, Luca
- Pedotti, Mattia
- Mazzola, Federica
- Carta, Manfredi
- Eckhardt, Valeria
- D’Antuono, Rocco
- Virgilio, Tommaso
- González, Santiago F
- Varani, Luca
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Bardelli, M., Frontzek, K., Simonelli, L., Hornemann, S., Pedotti, M., Mazzola, F., Carta, M., Eckhardt, V., D’Antuono, R., Virgilio, T., González, S. F., Aguzzi, A., & Varani, L. (2018). A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity. PLoS Pathogens, 14(10), e1007335. https://doi.org/10.1371/journal.ppat.1007335
