Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder

Grünblatt, Edna; Werling, Anna Maria; Roth, Alexander; Romanos, Marcel; Walitza, Susanne

doi:10.5167/uzh-170441

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Grünblatt, E., Werling, A. M., Roth, A., Romanos, M., & Walitza, S. (2019). Association study and a systematic meta-analysis of the VNTR polymorphism in the 3’-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder. Journal of Neural Transmission, 126(4), 517–529. https://doi.org/10.1007/s00702-019-01998-x

Abstract

Attention-deficit hyperactivity disorder (ADHD) has been postulated to associate with dopaminergic dysfunction, including the dopamine transporter (DAT1). Several meta-analyses showed small but significant association between the 10-repeat allele in the DAT1 gene in 3'-untranslated region variant number tandem repeat polymorphism and child and adolescent ADHD, whereas in adult ADHD the 9-repeat allele was suggested to confer as risk allele. Interestingly, recent evidence indicated that the long-allele variants (10 repeats and longer)