Extracorporeal photopheresis as second-line treatment therapy in life-threatening primary graft dysfunction following lung transplantation

Robinson, Cécile A; Inci, Ilhan; Naegeli, Mirjam; Murer, Christian; Schuurmans, Macé M; Urosevic-Maiwald, Mirjana; Schüpbach, Reto; Weder, Walter; Benden, Christian

doi:10.1111/petr.13145

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Robinson, C. A., Inci, I., Naegeli, M., Murer, C., Schuurmans, M. M., Urosevic-Maiwald, M., Schüpbach, R., Weder, W., & Benden, C. (2018). Extracorporeal photopheresis as second-line treatment therapy in life-threatening primary graft dysfunction following lung transplantation. Pediatric Transplantation, 22(3), e13145. https://doi.org/10.1111/petr.13145

Abstract

ECP is an established "second-line" treatment for CLAD/BOS. Recently, ECP was used for the first time in an adolescent CF patient as a "second-line" treatment therapy in life-threatening primary graft dysfunction following lung transplantation who deteriorated despite extensive treatment including ECMO and ATG. Within 10 days after initiation of ECP twice weekly, allograft function and clinical status improved significantly and the patient was weaned from mechanical ventilation support. ECP has been continued every 2 weeks since. Two