Publication: Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells
Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells
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Date
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Russkamp, N. F., Myburgh, R., Kiefer, J. D., Neri, D., & Manz, M. G. (2021). Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells. Experimental Hematology, 95, 31–45. https://doi.org/10.1016/j.exphem.2021.01.003
Abstract
Abstract
Abstract
Precise replacement of diseased or dysfunctional organs is the goal of regenerative medicine and has appeared to be a distant goal for a long time. In the field of hematopoietic stem cell transplantation, this goal is now becoming tangible as gene-editing technologies and novel conditioning agents are entering the clinical arena. Targeted immunologic depletion of hematopoietic stem cells (HSCs), which are at the very root of the hematopoietic system, will enable more selective and potentially more effective hematopoietic stem cell tra
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Creators (Authors)
- Russkamp, Norman F
- Myburgh, Renier
- Kiefer, Jonathan D
- Neri, Dario
- Manz, Markus G
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Citations
Russkamp, N. F., Myburgh, R., Kiefer, J. D., Neri, D., & Manz, M. G. (2021). Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells. Experimental Hematology, 95, 31–45. https://doi.org/10.1016/j.exphem.2021.01.003
