Publication: Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection
Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection
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Romito, M., Juillerat, A., Kok, Y. L., Hildenbeutel, M., Rhiel, M., Andrieux, G., Geiger, J., Rudolph, C., Mussolino, C., Duclert, A., Metzner, K. J., Duchateau, P., Cathomen, T., & Cornu, T. I. (2021). Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection. Biotechnology Journal, 16(1), 2000023. https://doi.org/10.1002/biot.202000023
Abstract
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Abstract
Therapies to treat patients infected with human immunodeficiency virus (HIV) aim at preventing viral replication but fail to eliminate the virus. Although transplantation of allogeneic CCR5Δ32 homozygous stem cell grafts provided a cure for a few patients, this approach is not considered a general therapeutic strategy because of potential side effects. Conversely, gene editing to disrupt the C-C chemokine receptor type 5 (CCR5) locus, which encodes the major HIV coreceptor, has shown to confer resistance to CCR5-tropic HIV strains. He
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Creators (Authors)
- Romito, Marianna
- Juillerat, Alexandre
- Kok, Yik Lim
- Hildenbeutel, Markus
- Rhiel, Manuel
- Andrieux, Geoffroy
- Geiger, Johannes
- Rudolph, Carsten
- Mussolino, Claudio
- Duclert, Aymeric
- Metzner, Karin J
- Duchateau, Philippe
- Cathomen, Toni
- Cornu, Tatjana I
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Citations
Romito, M., Juillerat, A., Kok, Y. L., Hildenbeutel, M., Rhiel, M., Andrieux, G., Geiger, J., Rudolph, C., Mussolino, C., Duclert, A., Metzner, K. J., Duchateau, P., Cathomen, T., & Cornu, T. I. (2021). Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection. Biotechnology Journal, 16(1), 2000023. https://doi.org/10.1002/biot.202000023
