Publication: A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
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Gingras, A. C., Caballero, M., Zarske, M., Sanchez, A., Hazbun, T. R., Fields, S., Sonenberg, N., Hafen, E., Raught, B., & Aebersold, R. (2005). A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Molecular & Cellular Proteomics, 4(11), 1725–1740. https://doi.org/10.1074/mcp.M500231-MCP200
Abstract
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Abstract
Using a combination of tandem affinity purification tagging and mass spectrometry, we characterized a novel, evolutionarily conserved protein phosphatase 4 (PP4)-containing complex (PP4cs, protein phosphatase 4, cisplatin-sensitive complex) that plays a critical role in the eukaryotic DNA damage response. PP4cs is comprised of the catalytic subunit PP4C; a known regulatory subunit, PP4R2; and a novel protein that we termed PP4R3. The Saccharomyces cerevisiae PP4R3 ortholog Psy2 was identified previously in a screen for sensitivity to
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- Gingras, A C
- Caballero, M
- Zarske, M
- Sanchez, Amy
- Hazbun, T R
- Fields, S
- Sonenberg, N
- Hafen, E
- Raught, B
- Aebersold, R
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Gingras, A. C., Caballero, M., Zarske, M., Sanchez, A., Hazbun, T. R., Fields, S., Sonenberg, N., Hafen, E., Raught, B., & Aebersold, R. (2005). A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Molecular & Cellular Proteomics, 4(11), 1725–1740. https://doi.org/10.1074/mcp.M500231-MCP200
