Publication: A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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Boege, Y., Malehmir, M., Healy, M. E., Wolf, M. J., Böhm, F., Frick, L., Maire, R., Moch, H., Heikenwalder, M., Weber, A., Lopes, M., & et al. (2017). A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell, 32(3), 342-359.e10. https://doi.org/10.1016/j.ccell.2017.08.010
Abstract
Abstract
Abstract
Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis. Proliferation-assoc
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Creators (Authors)
- Boege, Yannick
- Malehmir, Mohsen
- Healy, Marc E
- Wolf, Monika Julia
- Böhm, Friederike
- Frick, Lukas
- Maire, Renaud
- Moch, Holger
- Heikenwalder, Mathias
- Weber, Achim
- Lopes, Massimo
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Publications of Clinic for Gastroenterology and Hepatology
Publications of Clinic for Visceral and Transplantation Surgery
Publications of Institute of Molecular Cancer Research
Publications of Institute of Molecular Cancer Research
Publications of Institute of Physiology
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Citations
Boege, Y., Malehmir, M., Healy, M. E., Wolf, M. J., Böhm, F., Frick, L., Maire, R., Moch, H., Heikenwalder, M., Weber, A., Lopes, M., & et al. (2017). A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell, 32(3), 342-359.e10. https://doi.org/10.1016/j.ccell.2017.08.010
