Publication: Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation
Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation
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Pisano, F., Altomare, C., Cervio, E., Barile, L., Rocchetti, M., Ciuffreda, M. C., Malpasso, G., Copes, F., Manuela, M., Patrizia, D., Viarengo, G., Zaza, A., & Gnecchi, M. (2015). Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation. Stem Cells, 33(4), 1187–1199. https://doi.org/10.1002/stem.1928
Abstract
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Abstract
Several studies have demonstrated that miRNA are involved in cardiac development, stem cell maintenance and differentiation. In particular, it has been shown that miRNA133, miRNA1 and miRNA499 are involved in progenitor cell differentiation into cardiomyocytes. However, it is unknown whether different miRNA may act synergistically to improve cardiac differentiation. We used mouse P19 cells as a cardiogenic differentiation model. miRNA499, miRNA1 or miRNA133 were transiently over-expressed in P19 cells individually or in different comb
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- Pisano, Federica
- Altomare, Claudia
- Cervio, Elisabetta
- Barile, Lucio
- Rocchetti, Marcella
- Ciuffreda, Maria Chiara
- Malpasso, Giuseppe
- Copes, Francesco
- Viarengo, Gianluca
- Zaza, Antonio
- Gnecchi, Massimiliano
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Pisano, F., Altomare, C., Cervio, E., Barile, L., Rocchetti, M., Ciuffreda, M. C., Malpasso, G., Copes, F., Manuela, M., Patrizia, D., Viarengo, G., Zaza, A., & Gnecchi, M. (2015). Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation. Stem Cells, 33(4), 1187–1199. https://doi.org/10.1002/stem.1928