Publication: Defining the Molecular Landscape of Cancer-Associated Stroma in Cutaneous Squamous Cell Carcinoma
Defining the Molecular Landscape of Cancer-Associated Stroma in Cutaneous Squamous Cell Carcinoma
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Beebe, E., Motamed, Z., Opitz, L., Cheng, P. F., Levesque, M. P., Markkanen, E., & Feldmeyer, L. (2022). Defining the Molecular Landscape of Cancer-Associated Stroma in Cutaneous Squamous Cell Carcinoma. Journal of Investigative Dermatology, 142(12), 3304-3312.e5. https://doi.org/10.1016/j.jid.2022.06.017
Abstract
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Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer worldwide. Cancer-associated stroma (CAS) is central to tumor development and strongly influences therapy response. Perineural infiltration (PNI) represents a major risk factor for cSCC and likely influences CAS reprogramming. However, stromal reprogramming in cSCC remains poorly characterized, and it is unknown whether and how PNI influences CAS. To address these questions, we analyzed CAS and matched normal stroma from 20 cSCC cases (11 without PNI and 9
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- Beebe, Erin
- Motamed, Zahra
- Opitz, Lennart
- Feldmeyer, Laurence
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Beebe, E., Motamed, Z., Opitz, L., Cheng, P. F., Levesque, M. P., Markkanen, E., & Feldmeyer, L. (2022). Defining the Molecular Landscape of Cancer-Associated Stroma in Cutaneous Squamous Cell Carcinoma. Journal of Investigative Dermatology, 142(12), 3304-3312.e5. https://doi.org/10.1016/j.jid.2022.06.017
