Publication: Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.
Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.
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Rommel, C., Radziwill, G., Moelling, K., & Hafen, E. (1997). Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mechanisms of Development, 64(1–2), 95–104. https://doi.org/10.1016/S0925-4773(97)00052-X
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In the developing eye of Drosophila the protein kinase D-Raf controls the specification of the R7 photoreceptor cells. We show that overexpression of wild-type D-Raf inhibits the formation of R7 cells in a dose-dependent manner. Conversely, overexpression of mutant D-Raf proteins in which the conserved S388 is replaced by A or by D promotes the formation of supernumerary R7 cells, indicating increased D-Raf activity in vivo. S388 in D-Raf corresponds to S259 in c-Raf; shown to be involved in binding of 14-3-3. We show that analogous s
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- Rommel, C
- Radziwill, G
- Moelling, K
- Hafen, E
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Rommel, C., Radziwill, G., Moelling, K., & Hafen, E. (1997). Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mechanisms of Development, 64(1–2), 95–104. https://doi.org/10.1016/S0925-4773(97)00052-X