Publication: Early molecular insights into thanatin analogues binding to A. baumannii LptA
Early molecular insights into thanatin analogues binding to A. baumannii LptA
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Oi, K. K., Moehle, K., Schuster, M., & Zerbe, O. (2023). Early molecular insights into thanatin analogues binding to A. baumannii LptA. Molecules, 28, 4335. https://doi.org/10.3390/molecules28114335
Abstract
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Abstract
The cationic antimicrobial ß-hairpin, thanatin, was recently developed into drug-like analogues active against carbapenem-resistant Enterobacteriaceae (CRE). The analogues represent new antibiotics with a novel mode of action targeting LptA in the periplasm and disrupting LPS transport. The compounds lose antimicrobial efficacy when the sequence identity to E. coli LptA falls below 70%. We wanted to test the thanatin analogues against LptA of a phylogenetic distant organism and investigate the molecular determinants of inactivity. Aci
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- Oi, Kathryn K
- Moehle, Kerstin
- Schuster, Matthias
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Oi, K. K., Moehle, K., Schuster, M., & Zerbe, O. (2023). Early molecular insights into thanatin analogues binding to A. baumannii LptA. Molecules, 28, 4335. https://doi.org/10.3390/molecules28114335
