Publication: The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
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Oneda, B., Crettol, S., Jaquenoud Sirot, E., Bochud, M., Ansermot, N., & Eap, C. B. (2009). The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test. Pharmacogenetics and Genomics, 19, 877–883. https://doi.org/10.1097/FPC.0b013e32833225e7
Abstract
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BACKGROUND
CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with a large overlap in their specificities. We investigated the genetic bases that contribute to the variation of CYP3A activity.
METHODS
We phenotyped 251 individuals from two independent studies (182 patients treated with methadone and 69 patients with clozapine) for CYP3A activity using the midazolam phenotyping test and genotyped them for CYP3A4, CYP3A5, and CYP3A7 genetic variants, including the single nucleotide polymor
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Creators (Authors)
- Oneda, Beatrice
- Crettol, Severine
- Jaquenoud Sirot, Evelyne
- Bochud, Murielle
- Ansermot, Nicolas
- Eap, Chin B
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Oneda, B., Crettol, S., Jaquenoud Sirot, E., Bochud, M., Ansermot, N., & Eap, C. B. (2009). The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test. Pharmacogenetics and Genomics, 19, 877–883. https://doi.org/10.1097/FPC.0b013e32833225e7
