Prevalence and predictors of non-alcoholic steatohepatitis in subjects with morbid obesity and with or without type 2 diabetes

Lembo, Erminia; Russo, Maria Francesca; Verrastro, Ornella; Anello, Danila; Angelini, Giulia; Iaconelli, Amerigo; Guidone, Caterina; Stefanizzi, Gianluigi; Ciccoritti, Luigi; Greco, Francesco; Sessa, Luca; Riccardi, Laura; Pompili, Maurizio; Raffaelli, Marco; Vecchio, Fabio Maria; Bornstein, Stefan R; Mingrone, Geltrude; Gastaldelli, Amalia; Capristo, Esmeralda

doi:10.1016/j.diabet.2022.101363

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Lembo, E., Russo, M. F., Verrastro, O., Anello, D., Angelini, G., Iaconelli, A., Guidone, C., Stefanizzi, G., Ciccoritti, L., Greco, F., Sessa, L., Riccardi, L., Pompili, M., Raffaelli, M., Vecchio, F. M., Bornstein, S. R., Mingrone, G., Gastaldelli, A., & Capristo, E. (2022). Prevalence and predictors of non-alcoholic steatohepatitis in subjects with morbid obesity and with or without type 2 diabetes. Diabetes & Metabolism, 48(5), 101363. https://doi.org/10.1016/j.diabet.2022.101363

Abstract

AIM

To investigate the prevalence of biopsy-proven non-alcoholic steatohepatitis (NASH) in a cohort of patients with morbid obesity and with or without type 2 diabetes (T2D) and to find non-invasive predictors of NASH severity.

METHODS

We evaluated a cohort of 412 subjects (age 19-67 years, body mass index-BMI: 44.98 kg/m$^{2}$), who underwent fine-needle liver biopsy during bariatric surgery. Thirty-six percent of the subjects were affected by T2D. Liver biopsies were classified according to the Kleiner's NAFLD Activity Score (NAS