Publication: SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes
SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes
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Alves, L., Khosravi, M., Avila, M., Ader-Ebert, N., Bringolf, F., Zurbriggen, A., Vandevelde, M., & Plattet, P. (2015). SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes. Journal of Virology, 89(10), 5724–5733. https://doi.org/10.1128/JVI.00004-15
Abstract
Abstract
Abstract
Measles and canine distemper viruses (MeV and CDV, respectively) first replicate in lymphatic and epithelial tissues by using SLAM and nectin-4 as entry receptors, respectively. The viruses may also invade the brain to establish persistent infections, triggering fatal complications, such as subacute sclerosis pan-encephalitis (SSPE) in MeV infection or chronic, multiple sclerosis-like, multifocal demyelinating lesions in the case of CDV infection. In both diseases, persistence is mediated by viral nucleocapsids that do not require pac
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- Alves, Lisa
- Khosravi, Mojtaba
- Avila, Mislay
- Ader-Ebert, Nadine
- Bringolf, Fanny
- Zurbriggen, Andreas
- Vandevelde, Marc
- Plattet, Philippe
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Alves, L., Khosravi, M., Avila, M., Ader-Ebert, N., Bringolf, F., Zurbriggen, A., Vandevelde, M., & Plattet, P. (2015). SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes. Journal of Virology, 89(10), 5724–5733. https://doi.org/10.1128/JVI.00004-15