Publication: Human Plasma and Recombinant Hemopexins: Heme Binding Revisited
Human Plasma and Recombinant Hemopexins: Heme Binding Revisited
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Karnaukhova, E., Owczarek, C., Schmidt, P., Schaer, D. J., & Buehler, P. W. (2021). Human Plasma and Recombinant Hemopexins: Heme Binding Revisited. International Journal of Molecular Sciences, 22(3), 1199. https://doi.org/10.3390/ijms22031199
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Abstract
Plasma hemopexin (HPX) is the key antioxidant protein of the endogenous clearance pathway that limits the deleterious effects of heme released from hemoglobin and myoglobin (the term “heme” is used in this article to denote both the ferrous and ferric forms). During intra-vascular hemolysis, heme partitioning to protein and lipid increases as the plasma concentration of HPX declines. Therefore, the development of HPX as a replacement therapy during high heme stress could be a relevant intervention for hemolytic disorders. A logical ap
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Karnaukhova, E., Owczarek, C., Schmidt, P., Schaer, D. J., & Buehler, P. W. (2021). Human Plasma and Recombinant Hemopexins: Heme Binding Revisited. International Journal of Molecular Sciences, 22(3), 1199. https://doi.org/10.3390/ijms22031199