Publication: Generation of an antibody toolbox to characterize hERG
Generation of an antibody toolbox to characterize hERG
Date
Date
Date
Citations
Hausammann, G. J., Heitkamp, T., Matile, H., Gsell, B., Thoma, R., Schmid, G., Frasson, D., Sievers, M., Hennig, M., & Grütter, M. G. (2013). Generation of an antibody toolbox to characterize hERG. Biochemical and Biophysical Research Communications, 431(1), 70–75. https://doi.org/10.1016/j.bbrc.2012.12.089
Abstract
Abstract
Abstract
The human ether-a-go-go related gene (hERG) potassium channel plays a major role in the repolarization of the cardiac action potential. Inhibition of the hERG function by mutations or a wide variety of pharmaceutical compounds cause long QT syndrome and lead to potentially lethal arrhythmias. For detailed insights into the structural and biochemical background of hERG function and drug binding, the purification of recombinant protein is essential. Because the hERG channel is a challenging protein to purify, fast and easy techniques to
Additional indexing
Creators (Authors)
- Hausammann, Georg J
- Heitkamp, Thomas
- Matile, Hugues
- Gsell, Bernard
- Thoma, Ralf
- Schmid, Georg
- Frasson, David
- Sievers, Martin
- Hennig, Michael
- Grütter, Markus G
Journal/Series Title
Journal/Series Title
Journal/Series Title
Volume
Volume
Volume
Number
Number
Number
Page Range
Page Range
Page Range
Page end
Page end
Page end
Item Type
Item Type
Item Type
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Citations
Hausammann, G. J., Heitkamp, T., Matile, H., Gsell, B., Thoma, R., Schmid, G., Frasson, D., Sievers, M., Hennig, M., & Grütter, M. G. (2013). Generation of an antibody toolbox to characterize hERG. Biochemical and Biophysical Research Communications, 431(1), 70–75. https://doi.org/10.1016/j.bbrc.2012.12.089
