Multifunctional 3D electrode platform for real-time in situ monitoring and stimulation of cardiac tissues

Zhang, Ning; Stauffer, Flurin; Simona, Benjamin R; Zhang, Feng; Zhang, Zhao-Ming; Huang, Ning-Ping; Vörös, János

doi:10.1016/j.bios.2018.04.037

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Zhang, N., Stauffer, F., Simona, B. R., Zhang, F., Zhang, Z.-M., Huang, N.-P., & Vörös, J. (2018). Multifunctional 3D electrode platform for real-time in situ monitoring and stimulation of cardiac tissues. Biosensors & Bioelectronics, 112, 149–155. https://doi.org/10.1016/j.bios.2018.04.037

Abstract

Cardiovascular diseases are a major cause of death around the world underlining the importance of efficient treatments including novel medication. In vitro models of cardiac tissues are highly desired for monitoring electrophysiological response to screen pharmaceutical compounds at an early stage. Here, we report a platinum based 3D pillar electrode platform with cell growth guiding channel, which allows integrated, continuous electrical stimulation and recording of the cardiac tissues. This platform was successfully used to culture