Publication: Astrocyte glutathione maintains endothelial barrier stability
Astrocyte glutathione maintains endothelial barrier stability
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Huang, S.-F., Othman, A., Koshkin, A., Fischer, S., Fischer, D., Zamboni, N., Ono, K., Sawa, T., & Ogunshola, O. O. (2020). Astrocyte glutathione maintains endothelial barrier stability. Redox Biology, 34, 101576. https://doi.org/10.1016/j.redox.2020.101576
Abstract
Abstract
Abstract
Blood-brain barrier (BBB) impairment clearly accelerates brain disease progression. As ways to prevent injury-induced barrier dysfunction remain elusive, better understanding of how BBB cells interact and modulate barrier integrity is needed. Our metabolomic profiling study showed that cell-specific adaptation to injury correlates well with metabolic reprogramming at the BBB. In particular we noted that primary astrocytes (AC) contain comparatively high levels of glutathione (GSH)-related metabolites compared to primary endothelial ce
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- Huang, Sheng-Fu
- Othman, Alaa
- Koshkin, Alexey
- Fischer, Sabrina
- Fischer, David
- Zamboni, Nicola
- Ono, Katsuhiko
- Sawa, Tomohiro
- Ogunshola, Omolara O
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Huang, S.-F., Othman, A., Koshkin, A., Fischer, S., Fischer, D., Zamboni, N., Ono, K., Sawa, T., & Ogunshola, O. O. (2020). Astrocyte glutathione maintains endothelial barrier stability. Redox Biology, 34, 101576. https://doi.org/10.1016/j.redox.2020.101576
