Publication: pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis
pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis
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de Vallière, C., Cosin-Roger, J., Baebler, K., Schoepflin, A., Mamie, C., Mollet, M., Schuler, C., Bengs, S., Lang, S., Scharl, M., Seuwen, K., Ruiz, P. A., Hausmann, M., & Rogler, G. (2022). pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis. International Journal of Molecular Sciences, 23, 1419. https://doi.org/10.3390/ijms23031419
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Local extracellular acidification occurs at sites of inflammation. Proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) responds to decreases in extracellular pH. Our previous studies show a role for OGR1 in the pathogenesis of mucosal inflammation, suggesting a link between tissue pH and immune responses. Additionally, pH-dependent signalling is associated with the progression of intestinal fibrosis. In this study, we aimed to investigate OGR1 expression and OGR1-mediated signalling in patients with
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- de Vallière, Cheryl
- Cosin-Roger, Jesus
- Baebler, Katharina
- Schoepflin, Anja
- Mamie, Céline
- Mollet, Michelle
- Schuler, Cordelia
- Bengs, Susan
- Lang, Silvia
- Scharl, Michael
- Seuwen, Klaus
- Ruiz, Pedro A
- Hausmann, Martin
- Rogler, Gerhard
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de Vallière, C., Cosin-Roger, J., Baebler, K., Schoepflin, A., Mamie, C., Mollet, M., Schuler, C., Bengs, S., Lang, S., Scharl, M., Seuwen, K., Ruiz, P. A., Hausmann, M., & Rogler, G. (2022). pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis. International Journal of Molecular Sciences, 23, 1419. https://doi.org/10.3390/ijms23031419
