Publication: Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model
Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model
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Yakimovich, A., Gumpert, H., Burckhardt, C. J., Lutschg, V. A., Jurgeit, A., Sbalzarini, I. F., & Greber, U. F. (2012). Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model. Journal of Virology, 86(18), 10123–10137. https://doi.org/10.1128/JVI.01102-12
Abstract
Abstract
Abstract
Viruses spread between cells, tissues, and organisms by cell-free and cell-cell transmissions. Both mechanisms enhance disease development, but it is difficult to distinguish between them. Here, we analyzed the transmission mode of human adenovirus (HAdV) in monolayers of epithelial cells by wet laboratory experimentation and a computer simulation. Using live-cell fluorescence microscopy and replication-competent HAdV2 expressing green fluorescent protein, we found that the spread of infection invariably occurred after cell lysis. It
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Creators (Authors)
- Yakimovich, A
- Gumpert, H
- Burckhardt, C J
- Lutschg, V A
- Jurgeit, A
- Sbalzarini, I F
- Greber, U F
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Citations
Yakimovich, A., Gumpert, H., Burckhardt, C. J., Lutschg, V. A., Jurgeit, A., Sbalzarini, I. F., & Greber, U. F. (2012). Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model. Journal of Virology, 86(18), 10123–10137. https://doi.org/10.1128/JVI.01102-12
