Publication: Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms
Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms
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Melhem, H., Spalinger, M. R., Cosin-Roger, J., Atrott, K., Lang, S., Wojtal, K. A., Vavricka, S. R., Rogler, G., & Frey-Wagner, I. (2017). Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms. Journal of Crohn’s & Colitis, 11(7), 871–884. https://doi.org/10.1093/ecco-jcc/jjx016
Abstract
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Background and Aims An imbalance between cellular antioxidant defence system[s] and reactive oxygen species [ROS]-driven oxidative stress has been implicated in the pathogenesis of inflammatory bowel disease. Peroxiredoxin [PRDX] 6 contributes to an appropriate redox balance by clearing ROS and reducing peroxidized membrane phospholipids. We here studied the role of PRDX6 in acute and chronic dextran sodium sulphate [DSS]-induced colitis. Methods To investigate the impact of PRDX6 on intestinal inflammation, we used wild type [WT],
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- Melhem, Hassan
- Spalinger, Marianne R
- Cosin-Roger, Jesus
- Atrott, Kirstin
- Lang, Silvia
- Wojtal, Kacper A
- Vavricka, Stephan R
- Rogler, Gerhard
- Frey-Wagner, Isabelle
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Melhem, H., Spalinger, M. R., Cosin-Roger, J., Atrott, K., Lang, S., Wojtal, K. A., Vavricka, S. R., Rogler, G., & Frey-Wagner, I. (2017). Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms. Journal of Crohn’s & Colitis, 11(7), 871–884. https://doi.org/10.1093/ecco-jcc/jjx016
