Publication: Temporal variability and cell mechanics control robustness in mammalian embryogenesis
Temporal variability and cell mechanics control robustness in mammalian embryogenesis
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Date
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Fabrèges, D., Corominas-Murtra, B., Moghe, P., Kickuth, A., Ichikawa, T., Iwatani, C., Tsukiyama, T., Daniel, N., Gering, J., Stokkermans, A., Wolny, A., Kreshuk, A., Duranthon, V., Uhlman, V., Hannezo, E., & Hiiragi, T. (2024). Temporal variability and cell mechanics control robustness in mammalian embryogenesis. Science, 386(6718), eadh1145. https://doi.org/10.1126/science.adh1145
Abstract
Abstract
Abstract
How living systems achieve precision in form and function despite their intrinsic stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps of preimplantation embryogenesis in mouse, rabbit, and monkey embryos, and these morphomaps revealed that although blastomere divisions desynchronized passively, 8-cell embryos converged toward robust three-dimensional shapes. Using topological analysis and genetic perturbations, we found that embryos progressively changed their cellular connectivity to a preferred to
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Creators (Authors)
- Fabrèges, Dimitri
- Corominas-Murtra, Bernat
- Moghe, Prachiti
- Kickuth, Alison
- Ichikawa, Takafumi
- Iwatani, Chizuru
- Tsukiyama, Tomoyuki
- Daniel, Nathalie
- Gering, Julie
- Stokkermans, Anniek
- Wolny, Adrian
- Kreshuk, Anna
- Duranthon, Véronique
- Uhlman, Virginie
- Hannezo, Edouard
- Hiiragi, Takashi
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Citations
Fabrèges, D., Corominas-Murtra, B., Moghe, P., Kickuth, A., Ichikawa, T., Iwatani, C., Tsukiyama, T., Daniel, N., Gering, J., Stokkermans, A., Wolny, A., Kreshuk, A., Duranthon, V., Uhlman, V., Hannezo, E., & Hiiragi, T. (2024). Temporal variability and cell mechanics control robustness in mammalian embryogenesis. Science, 386(6718), eadh1145. https://doi.org/10.1126/science.adh1145
