Publication: RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
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Andrs, M., Hasanova, Z., Oravetzova, A., Dobrovolna, J., & Janscak, P. (2020). RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription. Genes, 11(2), 232. https://doi.org/10.3390/genes11020232
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RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsi
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- Andrs, Martin
- Hasanova, Zdenka
- Oravetzova, Anna
- Dobrovolna, Jana
- Janscak, Pavel
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Andrs, M., Hasanova, Z., Oravetzova, A., Dobrovolna, J., & Janscak, P. (2020). RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription. Genes, 11(2), 232. https://doi.org/10.3390/genes11020232
