Publication: Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors
Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors
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Echeverry, N., Ziltener, G., Barbone, D., Weder, W., Stahel, R. A., Broaddus, V. C., & Felley-Bosco, E. (2015). Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors. Cell Death and Disease, 6, e1757. https://doi.org/10.1038/cddis.2015.124
Abstract
Abstract
Abstract
Malignant pleural mesothelioma (MPM) originates in most of the cases from chronic inflammation of the mesothelium due to exposure to asbestos fibers. Given the limited effect of chemotherapy, a big effort is being made to find new treatment options. The PI3K/mTOR pathway was reported to be upregulated in MPM. We tested the cell growth inhibition properties of two dual PI3K/mTOR inhibitors NVP-BEZ235 and GDC-0980 on 19 MPM cell lines. We could identify resistant and sensitive lines; however, there was no correlation to the downregulati
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Creators (Authors)
- Echeverry, N
- Ziltener, G
- Barbone, D
- Weder, W
- Stahel, R A
- Broaddus, V C
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Citations
Echeverry, N., Ziltener, G., Barbone, D., Weder, W., Stahel, R. A., Broaddus, V. C., & Felley-Bosco, E. (2015). Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors. Cell Death and Disease, 6, e1757. https://doi.org/10.1038/cddis.2015.124
