Publication: Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behaviour of bladder cancer
Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behaviour of bladder cancer
Date
Date
Date
Citations
Leão, R., Lee, D., Figueiredo, A., Hermanns, T., Wild, P., Komosa, M., Lau, I., Mistry, M., Nunes, N. M., Price, A. J., Zhang, C., Lipman, T., Poyet, C., Valtcheva, N., Oehl, K., & et al. (2019). Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behaviour of bladder cancer. International Journal of Cancer, 144(7), 1676–1684. https://doi.org/10.1002/ijc.31935
Abstract
Abstract
Abstract
In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self-renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTp ) and epigenetic alterations in the TERT promoter may provide further insight into UBC behavior. Here, we investigated the combined effect of TERTp and the TERT Hypermethylated Oncological Region (THOR) status on telomerase activation and patient outcome in a UBC int
Additional indexing
Creators (Authors)
- Leão, Ricardo
- Lee, Donghyun
- Figueiredo, Arnaldo
- Hermanns, Thomas
- Wild, Peter
- Komosa, Martin
- Lau, Irene
- Mistry, Mathew
- Nunes, Nuno Miguel
- Price, Aryeh J
- Zhang, Cindy
- Lipman, Tatiana
- Poyet, Cédric
- Valtcheva, Nadejda
- Oehl, Kathrin
Volume
Volume
Volume
Number
Number
Number
Page Range
Page Range
Page Range
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Leão, R., Lee, D., Figueiredo, A., Hermanns, T., Wild, P., Komosa, M., Lau, I., Mistry, M., Nunes, N. M., Price, A. J., Zhang, C., Lipman, T., Poyet, C., Valtcheva, N., Oehl, K., & et al. (2019). Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behaviour of bladder cancer. International Journal of Cancer, 144(7), 1676–1684. https://doi.org/10.1002/ijc.31935
