Publication: Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma
Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma
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Amini, P., Nassiri, S., Ettlin, J., Malbon, A., & Markkanen, E. (2019). Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma. Disease Models & Mechanisms, 12(8), dmm.040444. https://doi.org/10.1242/dmm.040444
Abstract
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Abstract
Spontaneous canine simple mammary carcinomas (mCA) are often viewed as models of human mCA. Cancer-associated stroma (CAS) is central for initiation and progression of human cancer, and is likely to play a key role in canine tumours as well. However, canine CAS lacks characterisation and it remains unclear how canine and human CAS compare. Formalin-fixed paraffin embedded (FFPE) tissue constitutes a valuable resource of patient material, but chemical crosslinking has largely precluded its analysis by next-generation RNA sequencing (RN
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- Amini, Parisa
- Nassiri, Sina
- Ettlin, Julia
- Malbon, Alexandra
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Citations
Amini, P., Nassiri, S., Ettlin, J., Malbon, A., & Markkanen, E. (2019). Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma. Disease Models & Mechanisms, 12(8), dmm.040444. https://doi.org/10.1242/dmm.040444
