Publication: The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner
The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner
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Germani, F., Hain, D., Sternlicht, D., Moreno, E., & Basler, K. (2018). The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner. ELife, 7, e39939. https://doi.org/10.7554/eLife.39939
Abstract
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Abstract
The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In , apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell competition, which can be locally triggered by secreted factors released from winner cells. In this work, we provide evidence that the inhibition of Toll signaling not only increases the fitness of loser cells, but also bestows a clonal growth advan
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- Germani, Federico
- Hain, Daniel
- Sternlicht, Denise
- Moreno, Eduardo
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Citations
Germani, F., Hain, D., Sternlicht, D., Moreno, E., & Basler, K. (2018). The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner. ELife, 7, e39939. https://doi.org/10.7554/eLife.39939
