Publication: Understanding the Role of FUS in Synaptic RNA Homeostasis in Physiology and Neurodegeneration
Understanding the Role of FUS in Synaptic RNA Homeostasis in Physiology and Neurodegeneration
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Tantardini, E. (2024). Understanding the Role of FUS in Synaptic RNA Homeostasis in Physiology and Neurodegeneration. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-264370
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Fused in sarcoma (FUS) is a ubiquitously expressed protein that is associated with two neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). FUS is predominantly nuclear in healthy cells. However, in disease, it mislocalizes to the cytoplasm of the affected neurons, where it aggregates and forms protein inclusion, the pathological hallmark of ALS and FTD patients. Cytoplasmic mislocalization of FUS has been shown to lead to rapid synaptic impairment, which represents an early event triggeri
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Tantardini, E. (2024). Understanding the Role of FUS in Synaptic RNA Homeostasis in Physiology and Neurodegeneration. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-264370
