Publication: Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study
Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study
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Jomard, A., Liberale, L., Doytcheva, P., Reiner, M. F., Müller, D., Visentin, M., Bueter, M., Lüscher, T. F., Vettor, R., Lutz, T. A., Camici, G. G., & Osto, E. (2022). Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study. Scientific Reports, 12(1), 8664. https://doi.org/10.1038/s41598-022-12720-5
Abstract
Abstract
Abstract
Elevated circulating levels of nutrient-derived trimethylamine N-oxide (TMAO) have been associated with the onset and progression of cardiovascular disease by promoting athero-thrombosis. However, in conditions like bariatric surgery (Roux-en-Y gastric bypass, RYGB), stable increases of plasma TMAO are associated with improved endothelial function and reduced cardiovascular morbidity and mortality, thus questioning whether a mechanistic relationship between TMAO and endothelial dysfunction exists. Herein, we translationally assessed t
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Creators (Authors)
- Jomard, Anne
- Liberale, Luca
- Doytcheva, Petia
- Reiner, Martin F
- Müller, Daniel
- Visentin, Michele
- Bueter, Marco
- Lüscher, Thomas F
- Vettor, Roberto
- Camici, Giovanni G
- Osto, Elena
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In collections
Publications of Center for Molecular Cardiology
Publications of Clinic for Visceral and Transplantation Surgery
Publications of Institute of Clinical Chemistry
Publications of Institute of Pharmacology and Toxicology
Publications of Institute of Pharmacology and Toxicology
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Alfred and Annemarie von Sick Grants for Translational and Clinical Research Cardiology and Oncology
Swiss Life Foundation
Cardiovascular Research–Zurich Heart House
Sheikh Khalifa’s Foundation
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310030_197510
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Citations
Jomard, A., Liberale, L., Doytcheva, P., Reiner, M. F., Müller, D., Visentin, M., Bueter, M., Lüscher, T. F., Vettor, R., Lutz, T. A., Camici, G. G., & Osto, E. (2022). Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study. Scientific Reports, 12(1), 8664. https://doi.org/10.1038/s41598-022-12720-5
