Publication: Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm
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Hugelshofer, M., Buzzi, R. M., Schaer, C. A., Richter, H., Akeret, K., Anagnostakou, V., Mahmoudi, L., Vaccani, R., Vallelian, F., Deuel, J. W., Kronen, P. W., Kulcsár, Z., Regli, L., Baek, J. H., Pires, I. S., Palmer, A. F., Dennler, M., Humar, R., Buehler, P. W., … Schaer, D. J. (2019). Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm. Journal of Clinical Investigation, 129(12), 5219–5235. https://doi.org/10.1172/JCI130630
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Abstract
Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH) defining an unmet need for therapeutic development. Cell-free hemoglobin that is released from erythrocytes into the cerebrospinal fluid (CSF) is suggested to cause vasoconstriction and neuronal toxicity and correlates with the occurrence of DIND. Cell-free hemoglobin in the CSF of patients with aSAH disrupted dilatory NO signaling ex vivo in cerebral arteries, which shifted vascular tone balanc
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Creators (Authors)
- Hugelshofer, Michael
- Schaer, Christian A
- Richter, Henning
- Akeret, Kevin
- Anagnostakou, Vania
- Mahmoudi, Leila
- Vaccani, Raphael
- Vallelian, Florence
- Deuel, Jeremy W
- Kronen, Peter W
- Kulcsár, Zsolt
- Regli, Luca
- Baek, Jin Hyen
- Pires, Ivan S
- Palmer, Andre F
- Dennler, Matthias
- Humar, Rok
- Buehler, Paul W
- Kircher, Patrick R
- Schaer, Dominik J
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Hugelshofer, M., Buzzi, R. M., Schaer, C. A., Richter, H., Akeret, K., Anagnostakou, V., Mahmoudi, L., Vaccani, R., Vallelian, F., Deuel, J. W., Kronen, P. W., Kulcsár, Z., Regli, L., Baek, J. H., Pires, I. S., Palmer, A. F., Dennler, M., Humar, R., Buehler, P. W., … Schaer, D. J. (2019). Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm. Journal of Clinical Investigation, 129(12), 5219–5235. https://doi.org/10.1172/JCI130630
