Publication: Hemodilution causes glycocalyx shedding without affecting vascular endothelial barrier permeability in rats
Hemodilution causes glycocalyx shedding without affecting vascular endothelial barrier permeability in rats
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Ergin, B., Guerci, P., Uz, Z., Westphal, M., Ince, Y., Hilty, M., & Ince, C. (2020). Hemodilution causes glycocalyx shedding without affecting vascular endothelial barrier permeability in rats. Journal of Clinical and Translational Research, 5, 243–252. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453805/pdf/jclintranslres-2020-5-5-243.pdf
Abstract
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Abstract
Background
The consequences of acute normovolemic hemodilution (ANH) following different types of fluids on the different components of the glycocalyx and on vascular barrier permeability (VBP) remain unknown.
Aim
The aim of the study was to investigate whether the microcirculatory disruption and glycocalyx shedding induced by ANH alters VBP and whether this is affected by the composition and volume of the resuscitation fluid.
Materials and Methods
Anesthetized Wistar albino rats (n=24) underwent stepwise ANH at hematocrit levels
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Ergin, B., Guerci, P., Uz, Z., Westphal, M., Ince, Y., Hilty, M., & Ince, C. (2020). Hemodilution causes glycocalyx shedding without affecting vascular endothelial barrier permeability in rats. Journal of Clinical and Translational Research, 5, 243–252. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453805/pdf/jclintranslres-2020-5-5-243.pdf
