Publication: Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery
Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery
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Azimi, S. M., Sheridan, S. D., Ghannad-Rezaie, M., Eimon, P. M., & Yanik, M. F. (2018). Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery. ELife, 7, e31922. https://doi.org/10.7554/eLife.31922
Abstract
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Abstract
Identification of optimal transcription factor expression patterns to direct cellular differentiation along a desired pathway presents significant challenges. We demonstrate massively combinatorial screening of temporally-varying mRNA transcription factors to direct differentiation of neural progenitor cells using a dynamically-reconfigurable magnetically-guided spotting technology for localizing mRNA, enabling experiments on millimetre size spots. In addition, we present a time-interleaved delivery method that dramatically reduces fl
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- Azimi, Sayyed M
- Sheridan, Steven D
- Ghannad-Rezaie, Mostafa
- Eimon, Peter M
- Yanik, Mehmet Fatih
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Citations
Azimi, S. M., Sheridan, S. D., Ghannad-Rezaie, M., Eimon, P. M., & Yanik, M. F. (2018). Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery. ELife, 7, e31922. https://doi.org/10.7554/eLife.31922
