Publication: Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice
Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice
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Gado, M., Heinrich, A., Wiedersich, D., Sameith, K., Dahl, A., Alexaki, V. I., Swarbrick, M. M., Baschant, U., Grafe, I., Perakakis, N., Bornstein, S. R., Rauner, M., Hofbauer, L. C., & Henneicke, H. (2023). Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice. American Journal of Physiology. Endocrinology and Metabolism, 324(6), E514–E530. https://doi.org/10.1152/ajpendo.00259.2022
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Elevated serum concentrations of glucocorticoids (GCs) result in excessive lipid accumulation in white adipose tissue (WAT) as well as dysfunction of thermogenic brown adipose tissue (BAT), ultimately leading to the development of obesity and metabolic disease. Here, we hypothesized that activation of the sympathetic nervous system either via cold exposure or the use of a selective β3-adrenergic receptor (β3-AR) agonist alleviates the adverse metabolic effects of chronic GC exposure in rodents. To this end, male 10-wk-old C57BL/6NRj m
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- Gado, Manuel
- Heinrich, Annett
- Wiedersich, Denise
- Sameith, Katrin
- Dahl, Andreas
- Alexaki, Vasileia I
- Swarbrick, Michael M
- Baschant, Ulrike
- Grafe, Ingo
- Perakakis, Nikolaos
- Bornstein, Stefan R
- Rauner, Martina
- Hofbauer, Lorenz C
- Henneicke, Holger
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Gado, M., Heinrich, A., Wiedersich, D., Sameith, K., Dahl, A., Alexaki, V. I., Swarbrick, M. M., Baschant, U., Grafe, I., Perakakis, N., Bornstein, S. R., Rauner, M., Hofbauer, L. C., & Henneicke, H. (2023). Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice. American Journal of Physiology. Endocrinology and Metabolism, 324(6), E514–E530. https://doi.org/10.1152/ajpendo.00259.2022
