Publication: Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - from cardioprotection to functional repair in a translational pig infarction model
Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - from cardioprotection to functional repair in a translational pig infarction model
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Emmert, M. Y., Wolint, P., Jakab, A., Sheehy, S. P., Pasqualini, F. S., Nguyen, T. D. L., Hilbe, M., Seifert, B., Weber, B., Brokopp, C. E., Macejovska, D., Caliskan, E., von Eckardstein, A., Schwartlander, R., Vogel, V., Falk, V., Parker, K. K., Gyöngyösi, M., & Hoerstrup, S. P. (2017). Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - from cardioprotection to functional repair in a translational pig infarction model. Biomaterials, 122, 48–62. https://doi.org/10.1016/j.biomaterials.2016.11.029
Abstract
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To date, clinical success of cardiac cell-therapies remains limited. To enhance the cardioreparative properties of stem cells, the concept of lineage-specification through cardiopoietic-guidance has been recently suggested. However, so far, only results from murine studies and from a clinical pilot-trial in chronic heart-failure (CHF) are available, while systematic evidence of its therapeutic-efficacy is still lacking. Importantly, also no data from large animals or for other indications are available. Therefore, we here investigate
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Creators (Authors)
- Emmert, Maximilian Y
- Wolint, Petra
- Jakab, Andras
- Sheehy, Sean P
- Pasqualini, Francesco S
- Nguyen, Thi Dan Linh
- Hilbe, Monika
- Seifert, Burkhardt
- Weber, Benedikt
- Brokopp, Chad E
- Macejovska, Dominika
- Caliskan, Etem
- von Eckardstein, Arnold
- Schwartlander, Ruth
- Vogel, Viola
- Falk, Volkmar
- Parker, Kevin Kit
- Gyöngyösi, Mariann
- Hoerstrup, Simon P
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Publications of Epidemiology, Biostatistics and Prevention Institute (EBPI)
Publications of Institute for Regenerative Medicine (IREM)
Publications of Institute of Clinical Chemistry
Publications of Institute of Veterinary Pathology
Publications of Medical Clinic
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Emmert, M. Y., Wolint, P., Jakab, A., Sheehy, S. P., Pasqualini, F. S., Nguyen, T. D. L., Hilbe, M., Seifert, B., Weber, B., Brokopp, C. E., Macejovska, D., Caliskan, E., von Eckardstein, A., Schwartlander, R., Vogel, V., Falk, V., Parker, K. K., Gyöngyösi, M., & Hoerstrup, S. P. (2017). Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - from cardioprotection to functional repair in a translational pig infarction model. Biomaterials, 122, 48–62. https://doi.org/10.1016/j.biomaterials.2016.11.029
