Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

Yamada, Yoshito; Nguyen, Tuan Thanh; Impellizzieri, Daniela; Mineura, Katsutaka; Shibuya, Rintaro; Gomariz, Alvaro; Haberecker, Martina; Nilsson, Jakob; Nombela-Arrieta, César; Jungraithmayr, Wolfgang; Boyman, Onur

doi:10.1038/s41467-023-36924-z

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Yamada, Y., Nguyen, T. T., Impellizzieri, D., Mineura, K., Shibuya, R., Gomariz, A., Haberecker, M., Nilsson, J., Nombela-Arrieta, C., Jungraithmayr, W., & Boyman, O. (2023). Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice. Nature Communications, 14(1), 1383. https://doi.org/10.1038/s41467-023-36924-z

Abstract

Transplantation of solid organs can be life-saving in patients with end-stage organ failure, however, graft rejection remains a major challenge. In this study, by pre-conditioning with interleukin-2 (IL-2)/anti-IL-2 antibody complex treatment biased toward IL-2 receptor α, we achieved acceptance of fully mismatched orthotopic lung allografts that remained morphologically and functionally intact for more than 90 days in immunocompetent mice. These allografts are tolerated by the actions of forkhead box p3 (Foxp3)$^{+}$