Publication: Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect
Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect
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Imboden, M., Schwartz, J., Schindler, C., Curjuric, I., Berger, W., Liu, S. L. J., Russi, E. W., Ackermann-Liebrich, U., Rochat, T., & Probst-Hensch, N. M. (2009). Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect, 117, 1420–1427. https://doi.org/10.1289/ehp.0800430
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Background: Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution. Objective: We determined in 4,326 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPAL
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- Imboden, M
- Schwartz, J
- Schindler, C
- Curjuric, I
- Berger, W
- Liu, S L J
- Russi, E W
- Ackermann-Liebrich, U
- Rochat, T
- Probst-Hensch, N M
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Imboden, M., Schwartz, J., Schindler, C., Curjuric, I., Berger, W., Liu, S. L. J., Russi, E. W., Ackermann-Liebrich, U., Rochat, T., & Probst-Hensch, N. M. (2009). Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect, 117, 1420–1427. https://doi.org/10.1289/ehp.0800430
