A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven) on outcome after major liver resection

Linecker, Michael; Limani, Perparim; Botea, Florin; Popescu, Irinel; Alikhanov, Ruslan; Efanov, Michail; Kim, Pavel; Khatkov, Igor; Raptis, Dimitri Aristotele; Tschuor, Christoph; Beck-Schimmer, Beatrice; Bonvini, John; Wirsching, Andrea; Kron, Philipp; Slankamenac, Ksenija; Humar, Bostjan; Graf, Rolf; Petrowsky, Henrik; Clavien, Pierre-Alain

doi:10.1186/s12876-015-0331-1

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Linecker, M., Limani, P., Botea, F., Popescu, I., Alikhanov, R., Efanov, M., Kim, P., Khatkov, I., Raptis, D. A., Tschuor, C., Beck-Schimmer, B., Bonvini, J., Wirsching, A., Kron, P., Slankamenac, K., Humar, B., Graf, R., Petrowsky, H., & Clavien, P.-A. (2015). A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven) on outcome after major liver resection. BMC Gastroenterology, 15(102), online. https://doi.org/10.1186/s12876-015-0331-1

Abstract

BACKGROUND The body is dependent on the exogenous supply of omega-3 polyunsaturated fatty acids (n3-PUFA). These essential fatty acids are key players in regulating metabolic signaling but also exert anti-inflammatory and anti-carcinogenic properties. The liver is a major metabolic organ involved in fatty acid metabolism. Under experimental conditions, n3-PUFA exert beneficial effect on hepatic steatosis, regeneration and inflammatory insults such as ischemic injury after surgery. Some of these effects have also been observed in huma