Publication: DNA-Targeted Inhibition of MGMT
DNA-Targeted Inhibition of MGMT
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Marsoner, T., Schmidt, O. P., Triemer, T., & Luedtke, N. W. (2017). DNA-Targeted Inhibition of MGMT. Chembiochem, 18(10), 894–898. https://doi.org/10.1002/cbic.201600652
Abstract
Abstract
Abstract
The cationic porphyrin 5,10,15,20-tetrakis (diisopropyl-guanidine)-21H,23H-porphine (DIGPor) selectively binds to DNA containing O6 -methylguanine (O6 -MeG) and inhibits the DNA repair enzyme O6 -methylguanine-DNA methyltransferase (MGMT). The O6 -MeG selectivity and MGMT inhibitory activity of DIGPor were improved by incorporating ZnII into the porphyrin. The resulting metal complex (Zn-DIGPor) potentiated the activity of the DNA-alkylating drug temozolomide in an MGMT-expressing cell line. To the best of our knowledge, this is the f
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- Marsoner, Theodor
- Schmidt, Olivia P
- Triemer, Therese
- Luedtke, Nathan W
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Marsoner, T., Schmidt, O. P., Triemer, T., & Luedtke, N. W. (2017). DNA-Targeted Inhibition of MGMT. Chembiochem, 18(10), 894–898. https://doi.org/10.1002/cbic.201600652