Publication: Skeletal-Muscle Glutamine Synthase is Upregulated in Preclinical Prion Diseases
Skeletal-Muscle Glutamine Synthase is Upregulated in Preclinical Prion Diseases
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Caredio, D., Koderman, M., Frontzek, K., Sorce, S., Nuvolone, M., Bremer, J., Schwarz, P., Sellitto, S., Streichenberger, N., Scheckel, C., & Aguzzi, A. (2023). Skeletal-Muscle Glutamine Synthase is Upregulated in Preclinical Prion Diseases (No. 564879; BioRxiv). https://doi.org/10.1101/2023.10.31.564879
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In prion diseases, aggregates of misfolded prion protein (PrP$^{Sc}$) accumulate not only in the brain but can also be found in various extraneural tissues. This raises the question whether prion-specific pathologies arise also in these tissues. Here we sequenced mRNA transcripts in skeletal muscle, spleen and blood of prion-inoculated mice at eight timepoints during disease progression. We detected consistent gene-expression changes in all three organs, with skeletal muscle showing the most uniform alterations during disease progress
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Caredio, D., Koderman, M., Frontzek, K., Sorce, S., Nuvolone, M., Bremer, J., Schwarz, P., Sellitto, S., Streichenberger, N., Scheckel, C., & Aguzzi, A. (2023). Skeletal-Muscle Glutamine Synthase is Upregulated in Preclinical Prion Diseases (No. 564879; BioRxiv). https://doi.org/10.1101/2023.10.31.564879
