Publication: Regulation of ABCA1 by AMD-Associated Genetic Variants and Hypoxia in iPSC-RPE
Date
Date
Date
2022
Journal Article
Published version
Abstract
Abstract
Abstract
Age-related macular degeneration (AMD) is a progressive disease of the macula characterized by atrophy of the retinal pigment epithelium (RPE) and photoreceptor degeneration, leading to severe vision loss at advanced stages in the elderly population. Impaired reverse cholesterol transport (RCT) as well as intracellular lipid accumulation in the RPE are implicated in AMD pathogenesis. Here, we focus on ATP-binding cassette transporter A1 (ABCA1), a major cholesterol transport protein in the RPE, and analyze conditions that lead to ABCA
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5 since deposited on 2022-07-21
2last week
Acq. date: 2025-11-14
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1 since deposited on 2022-07-21
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Additional indexing
Creators (Authors)
- Peters, Florian
- Ebner, Lynn J A
- Atac, David
- Berger, Wolfgang
- den Hollander, Anneke I
Journal/Series Title
Journal/Series Title
Journal/Series Title
Volume
Volume
Volume
23
Number
Number
Number
6
Page range/Item number
Page range/Item number
Page range/Item number
3194
Item Type
Item Type
Item Type
Journal Article
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2022-03-16
Date available
Date available
Date available
2022-07-21
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
1422-0067
OA Status
OA Status
OA Status
Gold
Free Access at
Free Access at
Free Access at
Pubmed ID
Publisher DOI
Metrics
Downloads
5 since deposited on 2022-07-21
2last week
Acq. date: 2025-11-14
Views
1 since deposited on 2022-07-21
Acq. date: 2025-11-14
Gold Open Access
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