Publication: The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans
The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans
Date
Date
Date
Citations
Maxeiner, S., Grolleman, J., Schmid, T., Kammenga, J., & Hajnal, A. (2019). The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans. Life Science Alliance, 2(3), e201800255. https://doi.org/10.26508/lsa.201800255
Abstract
Abstract
Abstract
Animals need to adjust many cellular functions to oxygen availability to adapt to changing environmental conditions. We have used the nematode Caenorhabditis elegans as a model to investigate how variations in oxygen concentrations affect cell fate specification during development. Here, we show that several processes controlled by the conserved RTK/RAS/MAPK pathway are sensitive to changes in the atmospheric oxygen concentration. In the vulval precursor cells (VPCs), the hypoxia-inducible factor HIF-1 activates the expression of the
Additional indexing
Creators (Authors)
- Maxeiner, Sabrina
- Grolleman, Judith
- Schmid, Tobias
- Kammenga, Jan
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Maxeiner, S., Grolleman, J., Schmid, T., Kammenga, J., & Hajnal, A. (2019). The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans. Life Science Alliance, 2(3), e201800255. https://doi.org/10.26508/lsa.201800255
