Publication: Epileptiform Activity and Cognitive Deficits in SNAP-25+/- Mice are Normalized by Antiepileptic Drugs
Epileptiform Activity and Cognitive Deficits in SNAP-25+/- Mice are Normalized by Antiepileptic Drugs
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Corradini, I., Donzelli, A., Antonucci, F., Welzl, H., Loos, M., Martucci, R., De Astis, S., Pattini, L., Inverardi, F., Wolfer, D., Caleo, M., Bozzi, Y., Verderio, C., Frassoni, C., Braida, D., Clerici, M., Lipp, H.-P., Sala, M., & Matteoli, M. (2014). Epileptiform Activity and Cognitive Deficits in SNAP-25+/- Mice are Normalized by Antiepileptic Drugs. Cerebral Cortex, 24(2), 364–376. https://doi.org/10.1093/cercor/bhs316
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Synaptosomal-associated protein of 25 kDa (SNAP-25) is a protein that participates in the regulation of synaptic vesicle exocytosis through the formation of the soluble NSF attachment protein receptor complex and modulates voltage-gated calcium channels activity. The Snap25 gene has been associated with schizophrenia, attention deficit hyperactivity disorder, and bipolar disorder, and lower levels of SNAP-25 have been described in patients with schizophrenia. We used SNAP-25 heterozygous (SNAP-25(+/-)) mice to investigate at which ext
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Corradini, I., Donzelli, A., Antonucci, F., Welzl, H., Loos, M., Martucci, R., De Astis, S., Pattini, L., Inverardi, F., Wolfer, D., Caleo, M., Bozzi, Y., Verderio, C., Frassoni, C., Braida, D., Clerici, M., Lipp, H.-P., Sala, M., & Matteoli, M. (2014). Epileptiform Activity and Cognitive Deficits in SNAP-25+/- Mice are Normalized by Antiepileptic Drugs. Cerebral Cortex, 24(2), 364–376. https://doi.org/10.1093/cercor/bhs316