Mechanosensing and Sphingolipid-Docking Mediate Lipopeptide-Induced Immunity in Arabidopsis

Pršić, Jelena; Gilliard, Guillaume; Ibrahim, Heba; Argüelles-Arias, Anthony; Rondelli, Valeria; Crowet, Jean-Marc; Genva, Manon; Luzuriaga-Loaiza, W Patricio; Deboever, Estelle; Nasir, M Nail; Lins, Laurence; Mathelie-Guinlet, Marion; Boubsi, Farah; Eschrig, Sabine; Ranf, Stefanie; Dorey, Stephan; Coninck, Barbara De; Nürnberger, Thorsten; Mongrand, Sébastien; Höfte, Monica

doi:10.5167/uzh-253295

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Pršić, J., Gilliard, G., Ibrahim, H., Argüelles-Arias, A., Rondelli, V., Crowet, J.-M., Genva, M., Luzuriaga-Loaiza, W. P., Deboever, E., Nasir, M. N., Lins, L., Mathelie-Guinlet, M., Boubsi, F., Eschrig, S., Ranf, S., Dorey, S., Coninck, B. D., Nürnberger, T., Mongrand, S., … Ongena, M. (2023). Mechanosensing and Sphingolipid-Docking Mediate Lipopeptide-Induced Immunity in Arabidopsis (No. 547613; BioRxiv). https://doi.org/10.1101/2023.07.04.547613

Abstract

Bacteria-derived lipopeptides are immunogenic triggers of host defenses in metazoans and plants. Root-associated rhizobacteria produce cyclic lipopeptides that activate systemically induced resistance (IR) against microbial infection in various plants. How these molecules are perceived by plant cells remains elusive. Here, we reveal that immunity activation inArabidopsis thalianaby the lipopeptide elicitor surfactin is mediated by docking into specific sphingolipid-enriched domains and relies on host membrane deformation and subsequen