Publication: 24 hours in the life of HIV-1 in a T cell line
24 hours in the life of HIV-1 in a T cell line
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Mohammadi, P., Desfarges, S., Bartha, I., Joos, B., Zangger, N., Muñoz, M., Günthard, H. F., Beerenwinkel, N., Telenti, A., & Ciuffi, A. (2013). 24 hours in the life of HIV-1 in a T cell line. PLoS Pathogens, 9, e1003161. https://doi.org/10.1371/journal.ppat.1003161
Abstract
Abstract
Abstract
HIV-1 infects CD4+ T cells and completes its replication cycle in approximately 24 hours. We employed repeated measurements in a standardized cell system and rigorous mathematical modeling to characterize the emergence of the viral replication intermediates and their impact on the cellular transcriptional response with high temporal resolution. We observed 7,991 (73%) of the 10,958 expressed genes to be modulated in concordance with key steps of viral replication. Fifty-two percent of the overall variability in the host transcriptome
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- Mohammadi, Pejman
- Desfarges, Sébastien
- Bartha, István
- Joos, Beda
- Zangger, Nadine
- Muñoz, Miguel
- Günthard, Huldrych F
- Beerenwinkel, Niko
- Telenti, Amalio
- Ciuffi, Angela
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Mohammadi, P., Desfarges, S., Bartha, I., Joos, B., Zangger, N., Muñoz, M., Günthard, H. F., Beerenwinkel, N., Telenti, A., & Ciuffi, A. (2013). 24 hours in the life of HIV-1 in a T cell line. PLoS Pathogens, 9, e1003161. https://doi.org/10.1371/journal.ppat.1003161
