Publication: A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo
A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo
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Möller, K., Brambach, M., Villani, A., Gallo, E., Gilmour, D., & Peri, F. (2022). A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo. ELife, 11, e82094. https://doi.org/10.7554/elife.82094
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During brain development, many newborn neurons undergo apoptosis and are engulfed by microglia, the tissue-resident phagocytes of the brain, in a process known as efferocytosis. A hallmark of microglia is their highly branched morphology characterized by the presence of numerous dynamic extensions that these cells use for scanning the brain parenchyma and engulfing unwanted material. The mechanisms driving branch formation and apoptotic cell engulfment in microglia are unclear. By taking a live-imaging approach in zebrafish, we show t
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Möller, K., Brambach, M., Villani, A., Gallo, E., Gilmour, D., & Peri, F. (2022). A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo. ELife, 11, e82094. https://doi.org/10.7554/elife.82094
