Gravitational Force-Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells

Vahlensieck, Christian; Thiel, Cora Sandra; Zhang, Ye; Huge, Andreas; Ullrich, Oliver

doi:10.3390/ijms22179426

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Vahlensieck, C., Thiel, C. S., Zhang, Y., Huge, A., & Ullrich, O. (2021). Gravitational Force-Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells. International Journal of Molecular Sciences, 22(17), 9426. https://doi.org/10.3390/ijms22179426

Abstract

The mechanisms underlying gravity perception in mammalian cells are unknown. We have recently discovered that the transcriptome of cells in the immune system, which is the most affected system during a spaceflight, responds rapidly and broadly to altered gravity. To pinpoint potential underlying mechanisms, we compared gene expression and three-dimensional (3D) chromosomal conformational changes in human Jurkat T cells during the short-term gravitational changes in parabolic flight and suborbital ballistic rocket flight experiments. W